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This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.
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The Design and Analysis of Sequential Clinical Trials 2RevEd 9780471975502 Medicine Health Science Books Reviews :

This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.

John Whitehead,The Design and Analysis of Sequential Clinical Trials, 2.Rev.Ed.,Wiley,0471975508,Clinical trials - Statistical methods,Clinical trials;Statistical methods.,Biology, life sciences,Biostatistics,Clinical trials,General,Great Britain/British Isles,HC,HC/Mathematik/Wahrscheinlichkeitstheorie, Stochastik, Mathematische Statistik,HEALTH FITNESS / Healing,Healing,Health Fitness/Healing,MEDICAL,MEDICAL / Research,MEDICAL RESEARCH,Mathematics for scientists engineers,Mathematik,Medical/Research,Non-Fiction,Research,SCIENCE,SCIENCE / General,Scholarly/Graduate,Statistical methods,Wahrscheinlichkeitstheorie, Stochastik, Mathematische Statistik,patients; difference; treatment; trial; boundaries; sequential; design; approach; analysis; approaches; sequential clinical; alternative; treatments; two; comparison; implementation; examples; methods; pest; software; edition

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Product details Hardcover 328 pages Publisher Wiley; 2 edition (July 1997) Language English ISBN-10 0471975508

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